Sample: Serum, Citrate Plasma (See Instructions for Sample Collection)Ã‚Â
Remarks: Spontaneous Repetitive abortions without obvious causes By definition, repetitive miscarriage is the case when spontaneous abortions become most frequent than by chance alone (15% of all pregnancies will end in miscarriage). The evaluation of repetitive miscarriages is focused on Immunologic, Hormonal, Infections, Anatomical, Genetic and/or Coagulation causes.
Immunological causes: when womans immune system may inappropriately attack pregnancy tissues. Blood tests that help in the diagnosis of such a case are Anti-Cardiolipins antibodies (both IgG and IgM), Lupus Anticoagulant antibody, Anti Nuclear antibody, Anti Sperm antibody, Anti Ovary antibody and Anti Thyroid antibody.
Hormonal causes: A deficiency of the hormone Progesterone may prevent the successful implantation of a pregnancy into the inner wall of the uterus. Other hormonal disorders such as Thyroid hormones, Prolactin and Insulin may also be suggestive of hormonal causes of the miscarriage. The high Oestrogen levels of pregnancy may accentuate this tendency to clot, resulting in loss of blood flow to the pregnancy and resultant miscarriage.
Infections within the uterus are commonly implicated as causes of pregnancy loss later on in pregnancy. Early losses are rarely attributed to infection. Sometimes women who have suffered several early losses will be checked for vaginal bacterial imbalance or ureaplasma infection. Other infection that may be implicated in the late miscarriage are Chlamydial infection, CMV and/or Mycoplasma infections.
Genetics: Some women have inherited a genetic trait allowing their blood to clot too easily.