LKM Liver Kidney Microsomal
Sample: Serum
Schedule: Daily (IFA)
Units: Titer
Range: Negative
Remarks: Autoimmune Liver Ddisease includes Autoimmune Hepatitis, Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, and Autoimmune Cholangiopathy. It is characterised by chronic progressive inflammation that mey lead to liver cirrhosis. Serum of patients with Autoimmune hepatitis shows hypergammaglobulinaemia and high titre autoantibodies AMA and/or LKM.
Anti-mitochondrial antibodies (AMA) indicate Primary Biliary Cirrhosis and is most common in older females(Incidency: 90%). The cause is unknown but it is thought that infection might be a trigger.
On the other hand, about 90% of young females with Autoimmune Liver Disease may be grouped into types depending on positive for ANA (Antinuclear Antibody) and/or Anti Smooth Muscle Antibody (ASMA) or antibodies to Liver Kidney Micosomes (LKM).
