HbS Sickle Cell anaemia

Sample: Whole blood (EDTA, Heparin, Citrate, ACD.) 0.5 mL

Status: Accredited

Schedule: Daily (HPLC UV/VIS)

Units: % of total Hb .

Range: Up 1,0%

Remarks: Sickle Cell anaemia is caused by a variant of the beta-globin gene named Sickle haemoglobin (HbS). It is recessively inherited and either two copies (Homozygous) of HbS or one copy (Heterozygous) of HbS plus another beta-globin variant (such as HbD) are required for the disease expression. It is well known that HbS carriers are protected from Malaria infection, and this protection probably is the reason to the high frequency of Sickle Cell anaemia in the population of Africa and the Mediterranean region. Symptoms: Chronic anaemia, Splenic and/or Renal dysfunction, pain crises, and susceptibility to bacterial infections. The best way to measure the HbS haemoglobin is the HPLC/UV method: 

HPLC for Heterozigous HbS


Available tests