Carbamazepine (TEGRETOL)

Sample: Serum (taken just before the next dose)

Schedule: Daily

Units: μg/mL

Range: 8 - 12 μg/mL

Remarks: Carbamazepin is a potent antiepileptic drug and is effective alone or with other antiepileptic drugs in partial seizures. Note that the dose of carbamazepine cannot be used as a reliable index for predicting the serum concentration of either total or free carbamazepine serum concentrations in children with epilepsy.

Drug

Therapeutic Range

Toxic Level

Half-Live

Carbamazepine (Tegretol) 8 - 12 μg/mL > 12 μg/mL 15 - 40 hrs
Digitoxin

18 - 35 ng/mL

> 35 ng/mL

150 - 250 hrs

Digoxin

0.8 - 2.0 ng/mL

> 2.0 ng/mL

20 - 60 hrs

Phenobarbital

20 - 40 μg/mL

> 40 μg/mL

50 - 140 hrs

Phenytoin (Epanutin)

10 - 20 μg/mL

> 20 μg/mL

20 - 40 hrs

Valproic Acid (Depakene)

346 - 700 μmol/L

>700 μmol/L

8 - 15 hrs

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