Sample: Cervical Fld,Serum,Sperm, 0,5 mL
Schedule: Daily (Immunofluorescence)
Range: Females : Up 1:32 Males : Up 1:16
Remarks: The main cause of immunological infertility is the formation of sperm antibodies directed against spermatozoa antigens. Antisperm antibodies prevent the fertilization of the oocyte into the female genital tract and are therefore one of the major reasons for an immunologically induced infertility. Antisperm antibodies may be found both in men and in women and are divided in 4 groups:
- Frontal acrosome and post-capsular (mainly IgM type) sperm antibodies affect the interaction of the spermatozoon with the oocyte and the subsequent binding to and penetration of the zona pellucida.
- Equatorial (mainly IgG and IgA type) sperm antibodies found in the seminal and/or in the cervical fluids affect the penetration of the spermatozoa into the cervical mucus.
- Anti Tail (mainly IgG type) sperm antibodies inhibit the motility of spermatozoa by binding to their surface and by causing agglutination of the spermatozoa.